Common inquiries concerning Simbrinza (brinzolamide/brimonidine) What is the purpose of Simbrinza (brinzolamide/brimonidine)? Simbrinza (brinzolamide/brimonidine) is used to treat ocular hypertension, or elevated pressure inside the eye, which is brought on by open-angle glaucoma, the most prevalent kind of glaucoma.